N-hydroxypropan-2-amine hydrochloride (1:1)

N-hydroxypropan-2-amine hydrochloride (1:1) - Names and Identifiers

Name	N-hydroxypropan-2-amine hydrochloride (1:1)
Synonyms	N-ISOPROPYL HYDROXYLAMINE HCL 2-(Hydroxyamino)propanhydrochlorid N-Hydroxypropan-2-amine chlorhydrate N-Hydroxyisopropylamine hydrochloride N-IsoprpylhydroxylaMine hydrochloride N-Hydroxy-2-propanamine hydrochloride N-ISOPROPYLHYDROXYLAMINE HYDROCHLORIDE N-Isopropylhydroxylamine Hydrochloride N-Isopropylhydroxylamine hydrochloride N-(2-Propyl)hydroxylamine hydrochloride
CAS	50632-53-6 98425-98-0
InChI	InChI=1/C3H9NO.ClH/c1-3(2)4-5;/h3-5H,1-2H3;1H

N-hydroxypropan-2-amine hydrochloride (1:1) - Physico-chemical Properties

Molecular Formula	C3H10ClNO
Molar Mass	111.57
Melting Point	68-72 °C
Boling Point	104.9°C at 760 mmHg
Flash Point	44.5°C
Vapor Presure	16.5mmHg at 25°C
Appearance	Adhering Crystalline Powder
Color	White to beige
Storage Condition	Inert atmosphere,Store in freezer, under -20°C

N-hydroxypropan-2-amine hydrochloride (1:1) - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	3-10
HS Code	29280000

N-hydroxypropan-2-amine hydrochloride (1:1) - Reference Information

preparation

in a 2L three-mouth flask with magnetic stirring, 2-nitropropane, ethanol and concentrated sulfuric acid are dissolved in aqueous solution, and the reaction is stirred at 20~25 ℃ for 48h. Decompression distillation, concentration to remove ethanol, concentration residue added 450mL of water and 500mL of ethyl acetate extraction, standing, separation of organic phase, water phase and then 500mL of ethyl acetate extraction once, combined organic phase, decompression distillation, concentration to remove ethyl acetate. Add 45% sodium hydroxide aqueous solution dropwise to the aqueous phase to adjust the pH value to about 8, add 500mL of ethyl acetate for extraction twice, stand still, separate the organic phase, dry anhydrous sodium sulfate, filter, distill the filtrate under reduced pressure to remove ethyl acetate, concentrate the residue to be pale yellow oil, add 75.0g of 30% hydrogen chloride-ethanol solution dropwise at 20~25 ℃ in a 1L three-mouth flask with magnetic stirring and constant pressure dropping funnel, and drop it for 30min, continue to keep the temperature at 20~25 ℃, stir for 30min, add 250mL of anhydrous ether dropwise at 20~25 ℃, slowly precipitate white crystal precipitate, continue to keep the temperature at 4h, filter, dry under reduced pressure at 45 ℃ for 8h to obtain white crystal.

Last Update：2024-04-09 02:00:09